UNAFold 3.8 is available as a free download on our software library. This download was checked by our antivirus and was rated as clean. The actual developer of the program is Rensselaer Polytechnic Institute. The following versions: 3.8, 3.7 and 3.6 are the most frequently downloaded ones by the program users. The program is included in Development Tools.
From the developer:
UNAFold is a comprehensive software package for nucleic acid folding and hybridization prediction. The name is derived from "Unified Nucleic Acid Folding". Folding of single-stranded RNA or DNA, or hybridization between two single-strands, is accomplished in a variety of ways. Partition functions can be computed to derive base pair probabilities and stochastic samples of foldings or hybridizations. Energy minimization methods compute minimum free energy foldings or hybridizations, and can also compute suboptimal foldings that mimic the performance of the famous mfold software.
For melting simulations, the package computes not just melting temperatures, but entire melting profiles.
You may want to check out more software, such as Allegro CL, SystemScripter or SESType, which might be related to UNAFold.